Macrodactyly of Toes, also known as macrodactyly of foot, is related to macrodactyly of toes, bilateral and macrodactyly of toes, unilateral. An important gene associated with Macrodactyly of Toes is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha).