Macroglossia

Macroglossia, also known as congenital macroglossia, is related to cleft palate, isolated and connective tissue disease. An important gene associated with Macroglossia is DPYD (Dihydropyrimidine Dehydrogenase), and among its related pathways/superpathways are Phospholipase-C Pathway and Extracellular matrix organization. The drug Gliclazide has been mentioned in the context of this disorder. Affiliated tissues include tongue and bone marrow, and related phenotypes are macroglossia and hypothyroidism