Macroglobulinemia

Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to lymphoplasmacytic lymphoma and monoclonal gammopathy of uncertain significance. An important gene associated with Macroglobulinemia is MYD88 (MYD88 Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Cyclophosphamide and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and liver, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and nervous system