Macular Holes, also known as macular hole, is related to microvascular complications of diabetes 5 and macular dystrophy, dominant cystoid. An important gene associated with Macular Holes is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Angiogenesis (CST). The drugs Midazolam and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include retina and eye, and related phenotypes are nervous system and cardiovascular system