Lyme Disease, also known as lyme neuroborreliosis, is related to babesiosis and human granulocytic anaplasmosis, and has symptoms including fever, headache and fatigue. An important gene associated with Lyme Disease is YBX3 (Y-Box Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Doxycycline and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include heart and skin, and related phenotypes are arthritis and cranial nerve paralysis