Lateral Sclerosis (PLS)

Lateral Sclerosis, also known as primary lateral sclerosis, is related to primary lateral sclerosis, juvenile and amyotrophic lateral sclerosis 2, juvenile, and has symptoms including ataxia, muscular fasciculation and hemiplegia. An important gene associated with Lateral Sclerosis is SPG7 (SPG7 Matrix AAA Peptidase Subunit, Paraplegin), and among its related pathways/superpathways are Neuroscience and Cytoskeletal Signaling. The drugs Mexiletine and Cannabidiol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and bone marrow, and related phenotypes are spasticity and upper motor neuron dysfunction