Lethal Acantholytic Erosive Disorder is related to arrhythmogenic right ventricular dysplasia, familial, 6 and familial isolated arrhythmogenic ventricular dysplasia, left dominant form. An important gene associated with Lethal Acantholytic Erosive Disorder is DSP (Desmoplakin), and among its related pathways/superpathways are DREAM Repression and Dynorphin Expression and Keratinization. Affiliated tissues include skin, and related phenotypes are respiratory failure and absent eyelashes