Late Congenital Syphilis, also known as neurosyphilis, juvenile, is related to nephrotic syndrome and congenital syphilis, and has symptoms including gummatous ulcers, periosteal lesions and paresis. An important gene associated with Late Congenital Syphilis is C3orf18 (Chromosome 3 Open Reading Frame 18), and among its related pathways/superpathways is Angiogenesis (CST). Affiliated tissues include tongue and bone, and related phenotypes are cardiovascular system and immune system