Lissencephaly 8 (LIS8)

Lissencephaly 8, also known as lis8, is related to epilepsy, idiopathic generalized 14 and schuurs-hoeijmakers syndrome. An important gene associated with Lissencephaly 8 is TMTC3 (Transmembrane O-Mannosyltransferase Targeting Cadherins 3), and among its related pathways/superpathways are Vesicle-mediated transport and Rab regulation of trafficking. Affiliated tissues include cerebellum and cortex, and related phenotypes are intellectual disability and global developmental delay