Lissencephaly 3 (LIS3)

Lissencephaly 3, also known as lissencephaly due to tuba1a mutation, is related to lissencephaly 2 and lissencephaly type 3-familial fetal akinesia sequence syndrome, and has symptoms including ataxia and seizures. An important gene associated with Lissencephaly 3 is TUBA1A (Tubulin Alpha 1a), and among its related pathways/superpathways are Neurogenesis regulation in the olfactory epithelium and Reelin signaling pathway. Affiliated tissues include brain and cerebellum, and related phenotypes are global developmental delay and ventriculomegaly