Laron Syndrome (LARS)

Alias:

Growth Hormone Insensitivity Syndrome

Growth Hormone Receptor Deficiency

Laron-Type Isolated Somatotropin Defect

Laron-Type Dwarfism

Laron Dwarfism

Primary Growth Hormone Resistance

Pituitary Dwarfism Ii

Primary Gh Resistance

Short Stature Due to a Defect in Growth Hormone Receptor or Post-Receptor Pathway

Short Stature Due to Growth Hormone Resistance

Complete Growth Hormone Insensitivity

Primary Growth Hormone Insensitivity

Primary Gh Insensitivity

Gh Receptor Deficiency

Ghis

Laron Type Pituitary Dwarfism I

Growth Hormone Receptor Defect

Laron-Type Pituitary Dwarfism

Laron-Type Short Stature

Severe Gh Insensitivity

Gh-R Deficiency

Lars

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Basic Information

Medical Symptom

Gene & Mutation

Related Drugs

Disease Model

References Literature

Laron Syndrome, also known as growth hormone insensitivity syndrome, is related to growth hormone deficiency and isolated growth hormone deficiency. An important gene associated with Laron Syndrome is GHR (Growth Hormone Receptor), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Mecasermin and Insulin have been mentioned in the context of this disorder. Affiliated tissues include pituitary and bone, and related phenotypes are delayed skeletal maturation and abnormal facial shape

Related ID：

MALACARDS：LRN002

OMIM：262500

MESH：D046150