Large Cell Acanthoma, also known as large-cell acanthoma, is related to bowen's disease and acanthoma. An important gene associated with Large Cell Acanthoma is RFNG (RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Cytoskeletal Signaling. Affiliated tissues include skin, and related phenotypes are limbs/digits/tail and craniofacial