Landau-Kleffner Syndrome (LKS)

Landau-Kleffner Syndrome, also known as acquired epileptic aphasia, is related to auditory agnosia and verbal auditory agnosia. An important gene associated with Landau-Kleffner Syndrome is GRIN2A (Glutamate Ionotropic Receptor NMDA Type Subunit 2A), and among its related pathways/superpathways are Transmission across Chemical Synapses and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Acetazolamide and Diazepam have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe, and related phenotypes are seizure and aphasia