Limited Scleroderma, also known as limited cutaneous systemic sclerosis, is related to systemic scleroderma and scleroderma, familial progressive. An important gene associated with Limited Scleroderma is IRF5 (Interferon Regulatory Factor 5), and among its related pathways/superpathways is Genes associated with the development of rheumatoid arthritis. The drugs Ropivacaine and Sodium citrate have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related phenotypes are autoimmunity and hypopigmented skin patches