Leukoplakia

Leukoplakia, also known as leukokeratosis of oral mucosa, is related to oral leukoplakia and oral cancer. An important gene associated with Leukoplakia is DKC1 (Dyskerin Pseudouridine Synthase 1), and among its related pathways/superpathways are COPI-independent Golgi-to-ER retrograde traffic and Keratinization. The drugs Ketorolac and Rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include tongue and cervix, and related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).