Leukodystrophy

Leukodystrophy, also known as leukodystrophies, is related to metachromatic leukodystrophy and leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism, and has symptoms including back pain, headache and pain. An important gene associated with Leukodystrophy is POLR3A (RNA Polymerase III Subunit A), and among its related pathways/superpathways are Pyrimidine metabolism and Sphingolipid metabolism. The drugs Cyclophosphamide and Busulfan have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related phenotypes are Reduced mammosphere formation and nervous system