Leigh Syndrome (LS)

Alias:

Leigh Disease

Leigh Syndrome Due to Mitochondrial Complex Iv Deficiency

Infantile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due to Mitochondrial Complex I Deficiency

Leigh Syndrome Due to Mitochondrial Complex Iii Deficiency

Necrotizing Encephalopathy, Infantile Subacute, of Leigh

Leigh Syndrome Due to Mitochondrial Complex V Deficiency

Subacute Necrotizing Encephalomyelopathy

Sne

Leigh Syndrome Due to Mitochondrial Complex Ii Deficiency

Necrotizing Encephalopathy Infantile Subacute of Leigh

Juvenile Subacute Necrotizing Encephalomyelopathy

Encephalopathy, Subacute Necrotizing, Infantile

Necrotizing Encephalopathy, Infantile Subacute

Encephalopathy, Subacute Necrotizing, Juvenile

Juvenile Subacute Necrotizing Encephalopathy

Infantile Necrotizing Encephalomyelopathy

Subacute Necrotising Encephalomyelopathy

Maternally Inherited Leigh Syndrome

Subacute Necrotising Encephalopathy

Leigh's Disease

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Basic Information

Medical Symptom

Gene & Mutation

Related Drugs

Disease Model

References Literature

Leigh Syndrome, also known as leigh disease, is related to mitochondrial complex iv deficiency, nuclear type 5 and mitochondrial dna-associated leigh syndrome, and has symptoms including ataxia, muscle spasticity and ophthalmoplegia. An important gene associated with Leigh Syndrome is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Cysteamine and Ubidecarenone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and eye, and related phenotypes are abnormality of movement and increased serum lactate

Related ID：

MALACARDS：LGH007

OMIM：256000

MESH：D007888

ICD11：672871576