Lig4 Syndrome (LIG4S)

Lig4 Syndrome, also known as dna ligase iv deficiency, is related to nijmegen breakage syndrome and immune deficiency disease. An important gene associated with Lig4 Syndrome is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Homology Directed Repair and DNA Damage. Affiliated tissues include skin and bone marrow, and related phenotypes are global developmental delay and microcephaly