Lactic Acidosis, also known as acidosis, lactic, is related to pyruvate dehydrogenase e1-alpha deficiency and myopathy, lactic acidosis, and sideroblastic anemia 1. An important gene associated with Lactic Acidosis is NDUFS4 (NADH:Ubiquinone Oxidoreductase Subunit S4), and among its related pathways/superpathways are Metabolism and glycolysis (BioCyc). The drugs Stavudine and Metformin have been mentioned in the context of this disorder. Affiliated tissues include liver and heart.