Locked-in Syndrome

Locked-in Syndrome, also known as cerebromedullospinal disconnection, is related to mutism and akinetic mutism, and has symptoms including hemiplegia, ophthalmoplegia and muscle weakness. An important gene associated with Locked-in Syndrome is CBS (Cystathionine Beta-Synthase). The drugs Midodrine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include eye and spinal cord, and related phenotypes are spasticity and diplopia