Leber Hereditary Optic Neuropathy, Modifier of (LOAM)

Leber Hereditary Optic Neuropathy, Modifier of, also known as leber hereditary optic neuropathy, is related to leber hereditary optic neuropathy, autosomal recessive 1 and leber optic atrophy and dystonia, and has symptoms including ataxia and static tremor. An important gene associated with Leber Hereditary Optic Neuropathy, Modifier of is MT-ND6 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6), and among its related pathways/superpathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Idebenone and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye and bone marrow, and related phenotypes are mitochondrial respiratory chain defects and slow decrease in visual acuity