Keratolytic Winter Erythema, also known as erythrokeratolysis hiemalis, is related to skin disease and erythrokeratoderma ''en cocardes''. An important gene associated with Keratolytic Winter Erythema is CTSB (Cathepsin B), and among its related pathways/superpathways is 8p23.1 copy number variation syndrome. Affiliated tissues include skin, and related phenotypes are erythema and hyperhidrosis