Kohler's Disease, also known as kohler disease, is related to osteochondrosis of the tarsal bone and avascular necrosis. An important gene associated with Kohler's Disease is GYPE (Glycophorin E (MNS Blood Group)), and among its related pathways/superpathways are Phospholipase-C Pathway and PI3K-Akt signaling pathway. Affiliated tissues include bone and navicular bone of foot, and related phenotype is craniofacial.