Juvenile Xanthogranuloma

Juvenile Xanthogranuloma, also known as multiple eruptive juvenile xanthogranuloma, is related to histiocytosis and cutaneous fibrous histiocytoma, and has symptoms including exanthema and pruritus. An important gene associated with Juvenile Xanthogranuloma is FSCN1 (Fascin Actin-Bundling Protein 1), and among its related pathways/superpathways are Innate Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Vemurafenib and Palbociclib have been mentioned in the context of this disorder. Affiliated tissues include skin and lung, and related phenotypes are glaucoma and multiple cafe-au-lait spots