Isolated Childhood Apraxia of Speech, also known as speech and language disorder with orofacial dyspraxia, is related to foxp2-related speech and language disorder and toe syndactyly, telecanthus, and anogenital and renal malformations. An important gene associated with Isolated Childhood Apraxia of Speech is FOXP2 (Forkhead Box P2). Affiliated tissues include tongue and brain, and related phenotypes are delayed speech and language development and abnormality of speech or vocalization