Irritable Bowel Syndrome, also known as irritable colon, is related to fibromyalgia and inflammatory bowel disease 1, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Irritable Bowel Syndrome is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Clarithromycin and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include colon and brain, and related phenotypes are homeostasis/metabolism and nervous system