Iron Overload in Africa, also known as african iron overload, is related to hfe hemochromatosis and siderosis. An important gene associated with Iron Overload in Africa is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Insulin receptor recycling. Affiliated tissues include liver and bone marrow, and related phenotypes are increased circulating ferritin concentration and hepatitis