Iron Metabolism Disease, also known as iron deficiency, is related to neurodegeneration with brain iron accumulation 1 and neurodegeneration with brain iron accumulation 3. An important gene associated with Iron Metabolism Disease is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Glucose / Energy Metabolism. The drugs Copper and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related phenotypes are homeostasis/metabolism and liver/biliary system