Intellectual Developmental Disorder, X-Linked 46, also known as mrx46, is related to non-syndromic x-linked intellectual disability 46 and intellectual developmental disorder, x-linked 12. An important gene associated with Intellectual Developmental Disorder, X-Linked 46 is ARHGEF6 (Rac/Cdc42 Guanine Nucleotide Exchange Factor 6). Affiliated tissues include brain, and related phenotypes are sensorineural hearing impairment and intellectual disability