Intellectual Developmental Disorder with Autism and Speech Delay, also known as autism, susceptibility to, 5, is related to autism and cerebellar atrophy, developmental delay, and seizures. An important gene associated with Intellectual Developmental Disorder with Autism and Speech Delay is TBR1 (T-Box Brain Transcription Factor 1). Affiliated tissues include cortex and brain, and related phenotypes are intellectual disability, severe and joint laxity