Intestinal Perforation, also known as perforation of intestine, is related to enterocolitis and peritonitis. An important gene associated with Intestinal Perforation is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Toll-Like receptor Signaling Pathways. The drugs Doripenem and Clavulanic acid have been mentioned in the context of this disorder. Affiliated tissues include liver and colon, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland