Internuclear Ophthalmoplegia, also known as mlf - [medial longitudinal fasciculus] syndrome, is related to facial paralysis and myasthenia gravis, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Internuclear Ophthalmoplegia is MOG (Myelin Oligodendrocyte Glycoprotein), and among its related pathways/superpathways are ECM proteoglycans and 1p36 copy number variation syndrome. The drugs Dalfampridine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include eye and pons, and related phenotypes are nervous system and muscle