Intrahepatic Cholestasis

Intrahepatic Cholestasis, also known as neonatal intrahepatic cholestasis, is related to cholestasis, intrahepatic, of pregnancy 3 and familial intrahepatic cholestasis, and has symptoms including icterus, hepatocellular jaundice and pruritus of pregnancy. An important gene associated with Intrahepatic Cholestasis is ABCB11 (ATP Binding Cassette Subfamily B Member 11), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Sorbitol and DL-alpha-Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include liver and placenta, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism