Insulin-Resistance Syndrome Type a, also known as insulin-resistant diabetes mellitus and acanthosis nigricans, is related to diabetes mellitus, insulin-resistant, with acanthosis nigricans and donohue syndrome. An important gene associated with Insulin-Resistance Syndrome Type a is INSR (Insulin Receptor). The drugs Empagliflozin and Insulin have been mentioned in the context of this disorder. Affiliated tissues include skin and ovary, and related phenotypes are type ii diabetes mellitus and delayed puberty