Inner Ear Disease, also known as labyrinthine dysfunction, is related to bilateral hypoactive labyrinth and meniere disease, and has symptoms including earache and vertigo. An important gene associated with Inner Ear Disease is BRF1 (BRF1 RNA Polymerase III Transcription Initiation Factor Subunit), and among its related pathways/superpathways are Myometrial relaxation and contraction pathways and Neuroscience. The drugs Prednisone and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain and bone, and related phenotypes are nervous system and homeostasis/metabolism