Indolent Systemic Mastocytosis (ISM)

Indolent Systemic Mastocytosis, also known as ism, is related to mast-cell leukemia and systemic mastocytosis. An important gene associated with Indolent Systemic Mastocytosis is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are PAK Pathway and Signaling by Receptor Tyrosine Kinases. The drugs Cladribine and Hydroxychloroquine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and skin, and related phenotypes are mastocytosis and abnormal mast cell morphology