Immune Dysregulation with Autoimmunity, Immunodeficiency, and Lymphoproliferation, also known as autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency, is related to pontocerebellar hypoplasia, type 14 and pontocerebellar hypoplasia, type 15, and has symptoms including diarrhea An important gene associated with Immune Dysregulation with Autoimmunity, Immunodeficiency, and Lymphoproliferation is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4). The drugs Tacrolimus and Basiliximab have been mentioned in the context of this disorder. Affiliated tissues include t cells and bone marrow, and related phenotypes are decreased circulating antibody level and splenomegaly