Immunodeficiency 26 (IMD26)

Immunodeficiency 26, also known as severe combined immunodeficiency due to dna-pkcs deficiency, is related to immunodeficiency 26 with or without neurologic abnormalities and adenosarcoma. An important gene associated with Immunodeficiency 26 is PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit), and among its related pathways/superpathways are DNA Damage and Retinoblastoma gene in cancer. Affiliated tissues include t cells and nk cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and endocrine/exocrine gland