Immunodeficiency 63 with Lymphoproliferation and Autoimmunity (IMD63)

Immunodeficiency 63 with Lymphoproliferation and Autoimmunity, also known as il2rb deficiency, is related to rheumatoid factor-negative polyarticular juvenile idiopathic arthritis and oligoarticular juvenile idiopathic arthritis. An important gene associated with Immunodeficiency 63 with Lymphoproliferation and Autoimmunity is IL2RB (Interleukin 2 Receptor Subunit Beta), and among its related pathways/superpathways are Signal Transduction and NF-kappaB Signaling. Affiliated tissues include nk cells and bone marrow, and related phenotypes are failure to thrive and decreased fetal movement