Immunodeficiency 15a (IMD15A)

Immunodeficiency 15a, also known as imd15a, is related to transient neonatal thrombocytopenia and immunodeficiency 26. An important gene associated with Immunodeficiency 15a is IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta), and among its related pathways/superpathways are NF-kappaB Signaling and DDX58/IFIH1-mediated induction of interferon-alpha/beta. Affiliated tissues include t cells and b cells, and related phenotypes are decreased proportion of memory b cells and decreased proportion of cd8-positive t cells