Immunodeficiency 11b with Atopic Dermatitis, also known as atopic dermatitis, elevated ige, and eosinophilia, is related to b-cell expansion with nfkb and t-cell anergy and lymphoma, mucosa-associated lymphoid type. An important gene associated with Immunodeficiency 11b with Atopic Dermatitis is CARD11 (Caspase Recruitment Domain Family Member 11), and among its related pathways/superpathways are NF-kappaB Signaling and T-cell activation SARS-CoV-2. Affiliated tissues include b cells and bone marrow, and related phenotypes are atopic dermatitis and eosinophilia