Immunodeficiency 14 (APDS)

Immunodeficiency 14, also known as activated pi3k-delta syndrome, is related to immunodeficiency 14a with lymphoproliferation, autosomal dominant and agammaglobulinemia. An important gene associated with Immunodeficiency 14 is PIK3CD (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta), and among its related pathways/superpathways are Innate Immune System and Infectious disease. The drugs Temsirolimus and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related phenotypes are recurrent respiratory infections and recurrent ear infections