Ichthyosis Hystrix, Lambert Type, also known as porcupine man, is related to ichthyosis, congenital, autosomal recessive 4b and ichthyosis. An important gene associated with Ichthyosis Hystrix, Lambert Type is KRT10 (Keratin 10). Affiliated tissues include skin, and related phenotypes are hyperkeratosis and orthokeratotic hyperkeratosis