Hypoxic Ischemic Encephalopathy, also known as encephalopathies hypoxic-ischemic, is related to asphyxia neonatorum and cardiac arrest. An important gene associated with Hypoxic Ischemic Encephalopathy is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Sevoflurane and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related phenotypes are Decreased viability in pancreas lineage and nervous system