Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, and Pallidal Degeneration (HARP)

Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, and Pallidal Degeneration, also known as harp syndrome, is related to neurodegeneration with brain iron accumulation 1 and retinitis pigmentosa, and has symptoms including muscle spasticity An important gene associated with Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, and Pallidal Degeneration is PANK2 (Pantothenate Kinase 2). Affiliated tissues include globus pallidus and bone marrow, and related phenotypes are spasticity and dysarthria