Hypomyelinating Leukoencephalopathy is related to leukodystrophy, hypomyelinating, 12 and leukodystrophy, hypomyelinating, 13. An important gene associated with Hypomyelinating Leukoencephalopathy is GJC2 (Gap Junction Protein Gamma 2), and among its related pathways/superpathways are RNA Polymerase III Transcription Initiation and Cytosolic sensors of pathogen-associated DNA.