Hypogonadotropic Hypogonadism 4 with or Without Anosmia, also known as kallmann syndrome 4, is related to hypogonadotropic hypogonadism 2 with or without anosmia and amed syndrome, digenic. An important gene associated with Hypogonadotropic Hypogonadism 4 with or Without Anosmia is PROK2 (Prokineticin 2), and among its related pathways/superpathways is Wnt / Hedgehog / Notch. Affiliated tissues include pituitary and olfactory bulb, and related phenotypes are obesity and absence of pubertal development