Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function is related to culler-jones syndrome and adamantinous craniopharyngioma. An important gene associated with Hypothyroidism Due to Deficient Transcription Factors Involved in Pituitary Development or Function is HESX1 (HESX Homeobox 1). Affiliated tissues include pituitary and thyroid, and related phenotypes are pituitary hypothyroidism and decreased thyroid-stimulating hormone level