Hypothyroidism, Congenital, Nongoitrous, 1 (CHNG1)

Hypothyroidism, Congenital, Nongoitrous, 1, also known as tsh resistance, is related to familial hyperthyroidism due to mutations in tsh receptor and hypothyroidism, congenital, nongoitrous, 4. An important gene associated with Hypothyroidism, Congenital, Nongoitrous, 1 is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Methimazole and Antithyroid Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid and pituitary, and related phenotypes are impaired sensitivity to thyroid stimulating hormone and congenital hypothyroidism