Hypokalemic Periodic Paralysis, Type 1 (HOKPP1)

Hypokalemic Periodic Paralysis, Type 1, also known as hypokalemic periodic paralysis, is related to hypokalemic periodic paralysis, type 2 and thyrotoxic periodic paralysis, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Hypokalemic Periodic Paralysis, Type 1 is CACNA1S (Calcium Voltage-Gated Channel Subunit Alpha1 S), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and CREB Pathway. The drugs Diclofenamide and Carbonic Anhydrase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and thyroid, and related phenotypes are periodic hypokalemic paresis and episodic hypokalemia